منابع مشابه
Kinetic studies on the hydroxylation of p-coumaric acid to caffeic acid by spinach-beet phenolase.
1. A spectrophotometric assay is described that enables the hydroxylation of p-coumaric acid to caffeic acid, catalysed by spinach-beet phenolase, to be followed continuously. 2. Initial-velocity and inhibitor studies indicate that the order of substrate addition is oxygen, p-coumaric acid and electron donor, with an irreversible step separating the binding of each substrate. 3. Caffeic acid is...
متن کاملp-Coumaric acid inhibition of CREB phosphorylation reduces cellular melanogenesis
We investigated the in vitro effects of p-coumaric acid on melanogenesis. The melanin content in B16F1 cells stimulated with p-coumaric acid significantly decreased (68 % vs. control) through inhibition of tyrosinase enzyme activity assessed using both cell-free and cellbased assays (46 and 27 % compared with control, respectively). In addition, stimulating B16F1 cells with p-coumaric acid redu...
متن کاملEffect of antioxidant protection by p-coumaric acid on low-density lipoprotein cholesterol oxidation.
Mechanisms in which p-coumaric acid (CA) acts as an antioxidant are not well understood. This study investigated whether CA can act as a direct scavenger of reactive oxygen species (ROS) and whether it minimizes the oxidation of low-density lipoprotein (LDL). Rats were administered CA in drinking water at low or high doses for 10, 21, and 30 days (uptakes were 29 and 317 mg/day, respectively). ...
متن کاملThe Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin
In this study, we aimed to investigate the effects of p-Coumaric acid (PCA) on cisplatin (CIS)-induced hepatotoxicity and nephrotoxicity in Wistar adult rats for 24 h compared to untreated control groups. In this experiment, 40 Wistar adult rats were utilized and divided randomly into five groups. After 24 h of CIS administration, liver and kidneys were harvested and assessed by H&E stainin...
متن کاملInfluence of p-coumaric acid on doxorubicin-induced oxidative stress in rat's heart.
The therapeutic value of doxorubicin (DOX) as anticancer antibiotic is limited by its cardiotoxicity. The implication of natural phenolic acids in the prevention of many pathologic diseases has been reported. Herein, the ability of p-coumaric (PC) acid, a member of phenolic acids, to protect rat's heart against DOX-induced oxidative stress was investigated. Three main groups of albino rats were...
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ژورنال
عنوان ژورنال: J. Chem. Soc.
سال: 1869
ISSN: 0368-1769
DOI: 10.1039/js8692200191